According to Sandkühler, neuroinflammatory diseases of the brain, environmental factors and even the person's own lifestyle can lead to activation of glial cells. Examples from the current literature are: depression, anxiety disorders and chronic stress, multiple sclerosis or Alzheimer's and diabetes, as well as lack of exercise and poor diet. Sandkühler: "Glial cells are an important factor in ensuring the equilibrium of a person's neuroinflammatory system." The study results give grounds for speculation that improvements in a person's lifestyle could have a beneficial impact upon this system and ensure that they generally suffer less pain or "minor niggles", says Sandkühler: "It is therefore in our own hands: thirty minutes of moderate exercise three or four times a week, a healthy diet and avoiding putting on excess weight can make a huge difference."
Article: Gliogenic LTP spreads widely in nociceptive pathways, M.T. Kronschläger, R. Drdla-Schutting, M. Gassner, S.D. Honsek, H.L. Teuchmann, J. Sandkühler, Science, doi: 10.1126/science.aah5715, published 10 November 2016.